diff --git a/Marlin/src/HAL/HAL_DUE/MarlinSerialUSB_Due.cpp b/Marlin/src/HAL/HAL_DUE/MarlinSerialUSB_Due.cpp
index c77387737517d258d2ea4a49ff0abec6b51fddc6..dc8edf9a3a24c837455f635c050e269b41352a86 100644
--- a/Marlin/src/HAL/HAL_DUE/MarlinSerialUSB_Due.cpp
+++ b/Marlin/src/HAL/HAL_DUE/MarlinSerialUSB_Due.cpp
@@ -36,6 +36,7 @@
 // Imports from Atmel USB Stack/CDC implementation
 extern "C" {
   bool usb_task_cdc_isenabled(void);
+  bool usb_task_cdc_dtr_active(void);
   bool udi_cdc_is_rx_ready(void);
   int udi_cdc_getc(void);
   bool udi_cdc_is_tx_ready(void);
@@ -56,9 +57,11 @@ int MarlinSerialUSB::peek(void) {
   if (pending_char >= 0)
     return pending_char;
 
+  // If USB CDC not enumerated or not configured on the PC side
   if (!usb_task_cdc_isenabled())
     return -1;
 
+  // If no bytes sent from the PC
   if (!udi_cdc_is_rx_ready())
     return -1;
 
@@ -73,9 +76,11 @@ int MarlinSerialUSB::read(void) {
     return ret;
   }
 
+  // If USB CDC not enumerated or not configured on the PC side
   if (!usb_task_cdc_isenabled())
     return -1;
 
+  // If no bytes sent from the PC
   if (!udi_cdc_is_rx_ready())
     return -1;
 
@@ -83,7 +88,10 @@ int MarlinSerialUSB::read(void) {
 }
 
 bool MarlinSerialUSB::available(void) {
+    /* If Pending chars */
   return pending_char >= 0 ||
+    /* or USB CDC enumerated and configured on the PC side and some
+       bytes where sent to us */
       (usb_task_cdc_isenabled() && udi_cdc_is_rx_ready());
 }
 
@@ -92,11 +100,22 @@ void MarlinSerialUSB::flush(void) {
 
 void MarlinSerialUSB::write(const uint8_t c) {
 
+  /* Do not even bother sending anything if USB CDC is not enumerated
+     or not configured on the PC side or there is no program on the PC
+     listening to our messages */
+  if (!usb_task_cdc_isenabled() || !usb_task_cdc_dtr_active())
+    return;
+
+  /* Wait until the PC has read the pending to be sent data */
   while (usb_task_cdc_isenabled() &&
+         usb_task_cdc_dtr_active() &&
         !udi_cdc_is_tx_ready()) {
   };
 
-  if (!usb_task_cdc_isenabled())
+  /* Do not even bother sending anything if USB CDC is not enumerated
+     or not configured on the PC side or there is no program on the PC
+     listening to our messages at this point */
+  if (!usb_task_cdc_isenabled() || !usb_task_cdc_dtr_active())
     return;
 
   // Fifo full
diff --git a/Marlin/src/HAL/HAL_DUE/usb/udi_cdc.c b/Marlin/src/HAL/HAL_DUE/usb/udi_cdc.c
index f8ae82cf8b82838592e1da53e4df7e3595a70eaf..c8ab19b4b395b9c613d071cade4d556b30e4ddc0 100644
--- a/Marlin/src/HAL/HAL_DUE/usb/udi_cdc.c
+++ b/Marlin/src/HAL/HAL_DUE/usb/udi_cdc.c
@@ -1012,7 +1012,7 @@ iram_size_t udi_cdc_read_buf(void* buf, iram_size_t size)
 	return udi_cdc_multi_read_buf(0, buf, size);
 }
 
-iram_size_t udi_cdc_multi_get_free_tx_buffer(uint8_t port)
+iram_size_t __attribute__((optimize("O0"))) udi_cdc_multi_get_free_tx_buffer(uint8_t port)
 {
 	irqflags_t flags;
 	iram_size_t buf_sel_nb, retval;
@@ -1097,7 +1097,7 @@ int udi_cdc_putc(int value)
 	return udi_cdc_multi_putc(0, value);
 }
 
-iram_size_t udi_cdc_multi_write_buf(uint8_t port, const void* buf, iram_size_t size)
+iram_size_t __attribute__((optimize("O0"))) udi_cdc_multi_write_buf(uint8_t port, const void* buf, iram_size_t size)
 {
 	irqflags_t flags;
 	uint8_t buf_sel;
diff --git a/Marlin/src/HAL/HAL_DUE/usb/usb_task.c b/Marlin/src/HAL/HAL_DUE/usb/usb_task.c
index bd004c9ca4025abbd29ffa2dba426a4b74042d00..711cbf9640f0e8e3218c32896d641b0132601c00 100644
--- a/Marlin/src/HAL/HAL_DUE/usb/usb_task.c
+++ b/Marlin/src/HAL/HAL_DUE/usb/usb_task.c
@@ -52,6 +52,7 @@
 
 static volatile bool main_b_msc_enable = false;
 static volatile bool main_b_cdc_enable = false;
+static volatile bool main_b_dtr_active = false;
 
 void HAL_idletask(void) {
   // Attend SD card access from the USB MSD -- Prioritize access to improve speed
@@ -69,7 +70,7 @@ void usb_task_msc_disable(void)               { main_b_msc_enable = false; }
 bool usb_task_msc_isenabled(void)             { return main_b_msc_enable; }
 
 bool usb_task_cdc_enable(const uint8_t port)  { return ((main_b_cdc_enable = true)); }
-void usb_task_cdc_disable(const uint8_t port) { main_b_cdc_enable = false; }
+void usb_task_cdc_disable(const uint8_t port) { main_b_cdc_enable = false; main_b_dtr_active = false; }
 bool usb_task_cdc_isenabled(void)             { return main_b_cdc_enable; }
 
 /*! \brief Called by CDC interface
@@ -87,12 +88,17 @@ void usb_task_cdc_config(const uint8_t port, usb_cdc_line_coding_t *cfg) {
     dwDTERate = cfg->dwDTERate;
 }
 
+
 void usb_task_cdc_set_dtr(const uint8_t port, const bool b_enable) {
+
+  // Keep DTR status
+  main_b_dtr_active = b_enable;
+
   //  Implement Arduino-Compatible kludge to enter programming mode from
   // the native port:
   //  "Auto-reset into the bootloader is triggered when the port, already
   // open at 1200 bps, is closed."
-    
+
   if (1200 == dwDTERate) {
     // We check DTR state to determine if host port is open (bit 0 of lineState).
     if (!b_enable)
@@ -102,6 +108,8 @@ void usb_task_cdc_set_dtr(const uint8_t port, const bool b_enable) {
   }
 }
 
+bool usb_task_cdc_dtr_active(void)             { return main_b_dtr_active; }
+
 /// Microsoft WCID descriptor
 typedef struct USB_MicrosoftCompatibleDescriptor_Interface {
   uint8_t bFirstInterfaceNumber;
diff --git a/Marlin/src/HAL/HAL_DUE/usb/usb_task.h b/Marlin/src/HAL/HAL_DUE/usb/usb_task.h
index f535c9df7ad8191af3fe8d9e5ee316e82ffc5d93..22328e6de4f5c4c4b552f05fd11dc42d062cf8db 100644
--- a/Marlin/src/HAL/HAL_DUE/usb/usb_task.h
+++ b/Marlin/src/HAL/HAL_DUE/usb/usb_task.h
@@ -78,6 +78,19 @@ void usb_task_cdc_disable(const uint8_t port);
  */
 void usb_task_cdc_set_dtr(const uint8_t port, const bool b_enable);
 
+/*! \brief Check if MSC is enumerated and configured on the PC side
+ */
+bool usb_task_msc_isenabled(void);
+
+/*! \brief Check if CDC is enumerated and configured on the PC side
+ */
+bool usb_task_cdc_isenabled(void);
+
+/*! \brief Check if CDC is actually OPEN by an application on the PC side
+ *  assuming DTR signal means a program is listening to messages
+ */
+bool usb_task_cdc_dtr_active(void);
+
 /*! \brief Called by UDC when USB Host request a extra string different
  * of this specified in USB device descriptor
  */